MovDisordV3, Main, Exploration, bibRecord, 001775

Brainstem metabolites in multiple system atrophy of cerebellar type: 3.0‐T magnetic resonance spectroscopy study

Identifieur interne : 001775 ( Main/Exploration ); précédent : 001774; suivant : 001776

Brainstem metabolites in multiple system atrophy of cerebellar type: 3.0‐T magnetic resonance spectroscopy study

Auteurs : Yuhei Takado [Japon] ; Hironaka Igarashi [Japon] ; Kenshi Terajima [Japon] ; Takayoshi Shimohata [Japon] ; Tetsutaro Ozawa [Japon] ; Kouichirou Okamoto [Japon] ; Masatoyo Nishizawa [Japon] ; Tsutomu Nakada [Japon]

Source :

Movement Disorders [ 0885-3185 ] ; 2011-06.

RBID : ISTEX:F12DA1506E022CC98E296D84C77B078BAB07E28D

Descripteurs français

Pascal (Inist)
- Atrophie multisystématisée, Cervelet, Inositol, Métabolite, Pathologie du système nerveux, Spectrométrie RMN.

English descriptors

KwdEn :
- Aged, Aspartic Acid (analogs & derivatives), Aspartic Acid (metabolism), Biological Markers (metabolism), Cerebellum, Choline (metabolism), Creatinine (metabolism), Dipeptides (metabolism), Feasibility Studies, Female, Glutamic Acid (metabolism), Glutamine (metabolism), Humans, Inositol, MRS, MSA‐C, Magnetic Resonance Spectroscopy (methods), Male, Medulla Oblongata (metabolism), Medulla Oblongata (pathology), Metabolite, Middle Aged, Multiple System Atrophy (metabolism), Multiple System Atrophy (pathology), Multiple system atrophy, NMR spectrometry, Nervous system diseases, Pons (metabolism), Pons (pathology), Protons (diagnostic use), Severity of Illness Index, UMSARS, biomarker, brainstem, myo‐inositol.
MESH :
- chemical , analogs & derivatives : Aspartic Acid.
- chemical , diagnostic use : Protons.
- chemical , metabolism : Aspartic Acid, Biological Markers, Choline, Creatinine, Dipeptides, Glutamic Acid, Glutamine.
- metabolism : Medulla Oblongata, Multiple System Atrophy, Pons.
- methods : Magnetic Resonance Spectroscopy.
- pathology : Medulla Oblongata, Multiple System Atrophy, Pons.
- Aged, Feasibility Studies, Female, Humans, Male, Middle Aged, Severity of Illness Index.

Abstract

Background: The aim of this study was to find biomarkers of disease severity in multiple system atrophy of cerebellar type by imaging disease specific regions using proton magnetic resonance spectroscopy on a 3.0 T system. Methods: We performed proton magnetic resonance spectroscopy separately in the pons and medulla on 12 multiple system atrophy of cerebellar type patients and 12 age and gender matched control subjects. The metabolite concentrations were estimated from single‐voxel proton magnetic resonance spectra measured by point resolved spectroscopy, which were then correlated with clinical severity using Part I, II, and IV of the unified multiple system atrophy rating scale. Results: Proton magnetic resonance spectroscopy showed that myo‐inositol concentrations in both the pons and medulla were significantly higher in multiple system atrophy of cerebellar type patients compared to those of the control subjects (P < 0.05). By contrast, total N‐acetylaspartate (the sum of N‐acetylaspartate and N‐acetylaspartylglutamate) and total choline compounds concentrations in both the pons and medulla were significantly lower in multiple system atrophy of cerebellar type patients compared to control subjects (P < 0.05). Creatine concentration in the pons was significantly higher in multiple system atrophy of cerebellar type patients compared to the control subjects (P < 0.05). Furthermore, a significant correlation was found between the myo‐inositol/creatine ratio in the pons and clinical severity, defined by the sum score of unified multiple system atrophy rating scale (I+II+IV) (r = 0.76, P < 0.01). Conclusion: Proton magnetic resonance spectroscopy, in conjunction with a 3.0 T system, can be feasible to detect part of pathological changes in the brainstem, such as gliosis and neuronal cell loss, and the metabolites can be used as biomarkers of clinical severity in multiple system atrophy of cerebellar type patients. © 2011 Movement Disorder Society

Url:

https://api.istex.fr/document/F12DA1506E022CC98E296D84C77B078BAB07E28D/fulltext/pdf

DOI: 10.1002/mds.23550

Affiliations:

Japon

Le document en format XML

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<term>Cerebellum</term>
<term>Choline (metabolism)</term>
<term>Creatinine (metabolism)</term>
<term>Dipeptides (metabolism)</term>
<term>Feasibility Studies</term>
<term>Female</term>
<term>Glutamic Acid (metabolism)</term>
<term>Glutamine (metabolism)</term>
<term>Humans</term>
<term>Inositol</term>
<term>MRS</term>
<term>MSA‐C</term>
<term>Magnetic Resonance Spectroscopy (methods)</term>
<term>Male</term>
<term>Medulla Oblongata (metabolism)</term>
<term>Medulla Oblongata (pathology)</term>
<term>Metabolite</term>
<term>Middle Aged</term>
<term>Multiple System Atrophy (metabolism)</term>
<term>Multiple System Atrophy (pathology)</term>
<term>Multiple system atrophy</term>
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<term>Nervous system diseases</term>
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<term>Biological Markers</term>
<term>Choline</term>
<term>Creatinine</term>
<term>Dipeptides</term>
<term>Glutamic Acid</term>
<term>Glutamine</term>
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<term>Multiple System Atrophy</term>
<term>Pons</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Medulla Oblongata</term>
<term>Multiple System Atrophy</term>
<term>Pons</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Feasibility Studies</term>
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<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Severity of Illness Index</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Atrophie multisystématisée</term>
<term>Cervelet</term>
<term>Inositol</term>
<term>Métabolite</term>
<term>Pathologie du   système nerveux</term>
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<front><div type="abstract" xml:lang="en">Background: The aim of this study was to find biomarkers of disease severity in multiple system atrophy of cerebellar type by imaging disease specific regions using proton magnetic resonance spectroscopy on a 3.0 T system. Methods: We performed proton magnetic resonance spectroscopy separately in the pons and medulla on 12 multiple system atrophy of cerebellar type patients and 12 age and gender matched control subjects. The metabolite concentrations were estimated from single‐voxel proton magnetic resonance spectra measured by point resolved spectroscopy, which were then correlated with clinical severity using Part I, II, and IV of the unified multiple system atrophy rating scale. Results: Proton magnetic resonance spectroscopy showed that myo‐inositol concentrations in both the pons and medulla were significantly higher in multiple system atrophy of cerebellar type patients compared to those of the control subjects (P < 0.05). By contrast, total N‐acetylaspartate (the sum of N‐acetylaspartate and N‐acetylaspartylglutamate) and total choline compounds concentrations in both the pons and medulla were significantly lower in multiple system atrophy of cerebellar type patients compared to control subjects (P < 0.05). Creatine concentration in the pons was significantly higher in multiple system atrophy of cerebellar type patients compared to the control subjects (P < 0.05). Furthermore, a significant correlation was found between the myo‐inositol/creatine ratio in the pons and clinical severity, defined by the sum score of unified multiple system atrophy rating scale (I+II+IV) (r = 0.76, P < 0.01). Conclusion: Proton magnetic resonance spectroscopy, in conjunction with a 3.0 T system, can be feasible to detect part of pathological changes in the brainstem, such as gliosis and neuronal cell loss, and the metabolites can be used as biomarkers of clinical severity in multiple system atrophy of cerebellar type patients. © 2011 Movement Disorder Society</div>
</front>
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<name sortKey="Okamoto, Kouichirou" sort="Okamoto, Kouichirou" uniqKey="Okamoto K" first="Kouichirou" last="Okamoto">Kouichirou Okamoto</name>
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<name sortKey="Takado, Yuhei" sort="Takado, Yuhei" uniqKey="Takado Y" first="Yuhei" last="Takado">Yuhei Takado</name>
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<name sortKey="Terajima, Kenshi" sort="Terajima, Kenshi" uniqKey="Terajima K" first="Kenshi" last="Terajima">Kenshi Terajima</name>
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Movement Disorders (revue)

Brainstem metabolites in multiple system atrophy of cerebellar type: 3.0‐T magnetic resonance spectroscopy study

Brainstem metabolites in multiple system atrophy of cerebellar type: 3.0‐T magnetic resonance spectroscopy study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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